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The possibility of altered safety and efficacy should be considered when ponstel mefenamic acid is used concomitantly with these drugs.

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Do not use any other over-the-counter coldallergyor pain medication without first asking your doctor or pharmacistMany medicines available over the counter contain medicines similar to mefenamic acidsuch as aspirinibuprofenketoprofenor naproxenIf you take certain products together you may accidentally take too much of this type of medicationRead the label of any other medicine you are using to see if it contains aspirinibuprofenketoprofenor naproxen.

Taking an NSAID can increase your risk of life-threatening heart or circulation problemsincluding heart attack or strokeThis risk will increase the longer you use an NSAIDDo not use this medicine just before or after having heart bypass surgeryalso called coronary artery bypass graftor CABG

Correct volume status in dehydrated or hypovolemic patients prior to initiating PonstelMonitor renal function in patients with renal or hepatic impairmentheart failuredehydrationor hypovolemia during use of Ponstelsee PRECAUTIONSDrug InteractionsAvoid the use of Ponstel in patients with advanced renal disease unless the benefits are expected to outweigh the risk of worsening renal functionIf Ponstel is used in patients with advanced renal diseasemonitor patients for signs of worsening renal function.

Mefenamic acid pharmacokinetics have not been investigated in subjects with renal insufficiencyGiven that mefenamic acidits metabolites and conjugates are primarily excreted by the kidneysthe potential exists for mefenamic acid metabolites to accumulatePonstel should not be administered to patients with pre-existing renal disease or in patients with significantly impaired renal functionsee WARNINGSRenal Toxicity and Hyperkalemia

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