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Monitor vital signs and observe the patient for signs and symptoms of opioid withdrawalThese may includebut are not limited tonauseavomitingdysphoriayawningsweatingtearingrhinorrheastuffy nosecraving for opioidspoor appetiteabdominal crampssense of fearskin erythemadisrupted sleep patternsfidgetinguneasinesspoor ability to focusmental lapsesmuscle aches or crampspupillary dilationpiloerectionfeverchanges in blood pressurepulse or temperatureanxietydepressionirritabilitybackachebone or joint painstremorssensations of skin crawling or fasciculationsIf signs or symptoms of withdrawal appearthe test is positive and no additional naloxone should be administered.
Difficulty sleepinganxietynervousnessabdominal pain/crampsnausea and/or vomitinglow energyjoint and muscle painand headache.
If a more rapid transition from agonist to antagonist therapy is deemed necessary and appropriate by the healthcare providermonitor the patient closely in an appropriate medical setting where precipitated withdrawal can be managed.
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