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The serum half-life of lincomycin may be prolonged in patients with severe impairment of renal function compared to patients with normal renal functionIn patients with abnormal hepatic functionserum half-life may be twofold longer than in patients with normal hepatic function.

The following reactions have been reported with the use of lincomycin and are listed by System Organ Class.

Because lincomycin therapy has been associated with severe colitis which may end fatallyit should be reserved for serious infections where less toxic antimicrobial agents are inappropriateas described in the INDICATIONS AND USAGE sectionIt should not be used in patients with nonbacterial infections such as most upper respiratory tract infections.

Patients should be counseled that antibacterial drugs including Lincocin should only be used to treat bacterial infectionsThey do not treat viral infectionse.gthe common coldWhen Lincocin is prescribed to treat a bacterial infectionpatients should be told that although it is common to feel better early in the course of therapythe medication should be taken exactly as directedSkipping doses or not completing the full course of therapy may1decrease the effectiveness of the immediate treatment and2increase the likelihood that bacteria will develop resistance and will not be treatable by Lincocin or other antibacterial drugs in the future.

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