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Coadministration with herbal preparations containing StJohn’s wortHypericum perforatumdue to the risk of decreased plasma concentrations and reduced clinical effects of nevirapinesee section 4.5

Viramune should not be used as the sole active antiretroviralas monotherapy with any antiretroviral has shown to result in viral resistance.

Body as a wholeFeversomnolencedrug withdrawalredistribution/accumulation of body fat.

Immediate-release tablets release the active substance immediatelyand prolonged-release tablets release it slowly over a few hourswhich allows it to be given less frequently.

Nevirapine metabolitesStudies using human liver microsomes indicated that the formation of nevirapine hydroxylated metabolites was not affected by the presence of dapsonerifabutinrifampicinand trimethoprim/sulfamethoxazoleKetoconazole and erythromycin significantly inhibited the formation of nevirapine hydroxylated metabolites.

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