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What is DNAWhat is a geneHow do genes direct the production of proteinsMore about How Genes Work.
Impact of Common and Low-Frequent SERPINA1 Genetic Variants on AAT Serum Level.
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Abnormal alpha-1 antitrypsin proteins may bind together to form a large moleculeor polymerthat cannot leave the liverThe accumulation of these polymers results in liver damageIn additionlung tissue is destroyed because not enough alpha-1 antitrypsin is available to protect against neutrophil elastasePolymers of alpha-1 antitrypsin may also contribute to excessive inflammationwhich may explain some of the other features of alpha-1 antitrypsin deficiencysuch as a skin condition called panniculitis.
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