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If bupropion is used concomitantly with a cyp inducer, it may be necessary to increase the dose of bupropion, but the maximum recommended dose should not be exceeded.

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Report any new or worsening symptoms to your doctorsuch asmood or behavior changesanxietydepressionpanic attackstrouble sleepingor if you feel impulsiveirritableagitatedhostileaggressiverestlesshyperactivementally or physicallyor have thoughts about suicide or hurting yourself.

Co-administration may cause serotonin syndrome Do not use concomitantly or initiate bupropion within 14 days of stopping an MAOI Converselyat least 14 days should be allowed after stopping bupropion before starting an MAOI antidepressant Starting bupropion in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased potential of serotonin syndrome If linezolid or IV methylene blue must be administereddiscontinue bupropion immediately and monitor for CNS toxicitymay resume 24 hours after last linezolid or methylene blue dose or after 2 weeks of monitoringwhichever comes first.

Smoking cessation may also cause new or worsening mental health problemssuch as depression.

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management of severe bupropion poisoning with intravenous lipid emulsion.

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